Safety, toxicology and efficacy in preclinical models

Before we can use microbubbles in humans, we have to make sure that they are safe to use and have been approved by the relevant authorities. To do this, we test the toxicity of the microbubbles in the laboratory to ensure that their use does not pose any serious health risks or side effects. We are also checking whether the ultrasound diagnosis of inflammatory bowel diseases and the monitoring of disease progression with the microbubbles work precisely. This is being carried out in collaboration with the Institutes of Laboratory Animal Science and Experimental Molecular Imaging at RWTH Aachen University Hospital. Thanks to the certification of the institutes, we can use the data obtained for the approval of the microbubbles in the next studies.

News:

15th October 2024 - We congratulate Jinwei Qi and colleagues on their research paper ‘Molecular Ultrasound Imaging With Clinically Translatable cRGD-Coated Microbubbles to Assess αvβ3-Integrin Expression in Inflammatory Bowel Disease’, which was published in Investigate Radiology and deals with the use of integrin-targeted microbubbles to detect intestinal inflammation.

11th April 2024 - The Climbing Crohn Team expresses its sincere thanks to all participants for the constructive discussions at the second Climbing Crohn status meeting.

We are happy to present our progress at the European Molecular Imaging Meeting and the World Molecular Imaging Congress in 2024, 2025 and 2026.